Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

Aim: The aim of the study was to investigate relationship between soluble suppression tumorigenicity 2 (sST2) level and degree epicardial blood flow recovery in patients with myocardial infarction ST-segment elevation (STEMI) after percutaneous coronary intervention. Material Methods: involved 61 (83.6% males), a mean age 59.85±10.01 years. sST2 measured by enzyme immunoassay. Patients were divided into two groups. first group (n=12) included thrombolysis (TIMI) ≤II grade, second (n=49) TIMI III grade. Results: significantly higher hours disease decreased (TIMI ≤II) intervention (p=0.003). Receiver operating characteristics curve analysis showed that levels over 34.2 ng/ml, detected on admission, an independent predictor adverse revascularization STEMI sensitivity 92.3% specificity 62.5%; area under 0.811 (95% CI: 0.651 - 0.873; p=0.001). Both univariate (OR: 1.020, 95% 1.001-1.041, p=0.028) multivariate 1.030; 1.002-1.057; p=0.033) analyzes significant unfavorable outcome vascular ≤ІІ). Conclusion: is highly associated great clinical importance as prognostic marker.